Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1)
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors.
The mechanistic basis for the tissue specific expression of cholesterol elimination pathways is poorly understood. To gain additional insight into this phenomenon we considered it of interest to investigate if epigenetic mechanisms are involved in the regulation of the brain-specific enzyme cholesterol 24-hydroxylase (CYP46A1), a key regulator of brain cholesterol elimination. We demonstrated a...
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PURPOSE Genetics has made significant contributions to the study of glaucoma over the past few decades. Cholesterol-24S-hydroxylase (CYP46A1) is a cholesterol-metabolizing enzyme that is especially expressed in retinal ganglion cells. CYP46A1 and its metabolic product, 24S-hydroxycholesterol, have been linked to neurodegeneration. A single-nucleotide polymorphism (SNP) in the CYP46A1 gene, desi...
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Cholesterol 7a-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation. The role of cholesterol in the regulation of cholesterol 7a-hydroxylase and the interrelationship between the cholesterol and bile acid biosynthesis pathways remain controversial. Th...
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A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct was selected for studying transcriptional regulation of CYP7A gene promoter. Insulin and phorbol 12-myristate-13-acetate (PMA) strongly repressed the promoter activity as measured with luciferase activity expressed in the cells. The promoter activity of the 5' progressi...
متن کاملThe brain-specifi c cholesterol 24-hydroxylase (CYP46A1) is a member of the cytochrome P450 superfamily of enzymes that catalyzes the hydroxylation of cholesterol into 24(S)-hydroxycholesterol (24OHC)
This article is available online at http://www.jlr.org The brain-specifi c cholesterol 24-hydroxylase (CYP46A1) is a member of the cytochrome P450 superfamily of enzymes that catalyzes the hydroxylation of cholesterol into 24(S)-hydroxycholesterol (24OHC) ( 1 ). The fl ux of this oxysterol across the blood-brain barrier represents the major mechanism of cholesterol elimination from the brain ha...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m505179200